Rac1 Activation Caused by Membrane Translocation of a Guanine Nucleotide Exchange Factor in Akt2-Mediated Insulin Signaling in Mouse Skeletal Muscle.
Insulin-stimulated glucose uptake in skeletal muscle is mediated by the glucose transporter GLUT4, which is translocated to the plasma membrane following Monitor Calibration insulin stimulation.Several lines of evidence suggested that the protein kinase Akt2 plays a key role in this insulin action.The small GTPase Rac1 has also been implicated as a